Hanahan and Weinberg:Cell, 2000 We suggest that research over the past decades has revealed small number of molecular, biochemical, and cellular associated genes be tied to the operations of a cell. Our faith in such simplifcation derives directly from the teachings of cell biology that virtually all mammalian cells carry a similar molecuar machinery regulating their proliferation, differentiation and death... One day, we imagine that cancer biology and treatment- at present, a patchwork quilt an endeavor that will depend on defining all of of cell biology, genetics, histopathology, biochemistry, immunology and pharmacology will become a science, with a conceptual structure and logical coherence that rivals that of chemistry or physics. Fig:Acquired capabilities of cancer